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Analysis of lead toxicity in human cells

Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants

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Using human myeloma cell lines obtained from the American Type Culture Collection (ATCC), the study demonstrated that PHD3 restoration, by using a lentivirus vector or overcoming PHD3 epigenetic silencing using a demethyltransferase inhibitor, 5-Aza-2-deoxycytidine (5-Aza-dC), suppresses hypoxia-driven HIF-2 stabilization, thereby promoting apoptotic cell death (197)