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Description
(1995) 90 Suppl 1:15
4B) via transamination reactions
General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain
& Butler, P
As the liver is the main site for metabolism of dietary copper, dysfunctional ATP7B leads to copper overload in hepatocytes, resulting in liver pathology, and excess copper, not bound to ceruloplasmin, is released into the circulation where it can pathologically accumulate in other tissues, including the brain (Czonkowska et al., 2018)
