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The crimp seal is applied at the end of the manufacturing process and provides visual verification that the vial has not been previously opened
The suitability of propofol compared with urethane for anesthesia during urodynamic studies in rats

Among them, IGFBP-5 is the most abundant in renal tissue, while IGFBP-3 is the most prevalent in circulation

So, there is no one-size-fits-all answer

Sterile water for injection is a single-use diluent once a vial is opened, it's considered non-sterile for subsequent withdrawals
