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[74], the results obtained were expected regardless of whether early exposure to APAP was responsible for most cases of ASD

and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

After centrifugation, the supernatant fluid was used for erythrocyte free amino acid analysis

Therefore, local Mediterranean herbs represent a promising natural source of Nrf2 activators in the development of adjunct therapies for vitiligo and may explain why incidence of vitiligo in the Mediterranean region remains less than other parts of the world