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Description
Both genetic circadian disruption and HFD feeding shifted adipocyte cell state from a pro-adipogenic signature towards an insulin resistant state 55,56
Most patients notice appetite suppression within the first 1 to 2 weeks and measurable weight loss within 4 to 8 weeks
Insulin response to a glucose challenge improved as well
References 1 HollySPGeraNWangPWilsonAGuanZLinLet al
Targeting lactate-related cell cycle activities for cancer therapy
