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The earliest signal is injection site behavior
Its stability is noteworthy: unlike many bioactive peptides, BPC-157 remains intact in gastric acid for extended periods, which is why oral administration routes have been investigated alongside subcutaneous and intramuscular protocols

Phase 1/2 clinical trials on the intradiscal injection of recombinant human growth and differentiation factor-5 (rhGDF-5) have reported promising results (NCT00813813 and NCT01124006)

doi: 10.1002/jnr.20562

The compound is often called simply dioxane because the other dioxane isomers (1,2- and 1,3-) are rarely encountered
