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Without magnesium to block calcium channels, the sympathetic nervous system (the "fight-or-flight" response) becomes hyperactive

Effects of folic acid supplementation on cognitive function and A-related biomarkers in mild cognitive impairment: A randomized controlled trial

Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)

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CICD occurs in caspase-dependent apoptosis when classical apoptotic signaling pathways are inhibited, as occurs, for example, when viral infections or caspase inhibitors are used (May and Madge 2007