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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (DeGregorio-Rocasolano et al., 2019)

Fatigue can have many causesincluding poor sleep, stress, thyroid disorders, or iron deficiencythat B12 injections cannot address

doi: 10.1074/jbc.M506727200 128 RuizL

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The NHS recommends: Site selection : Rotate between the abdomen (avoiding a 5cm radius around the navel), front of thighs, and outer upper arms to prevent lipohypertrophy