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Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

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This stress disrupts ferroptosis regulation, leading to tissue damage and inflammation

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5 Future directions and conclusion Despite decades of research, GBM remains one of the most challenging cancers to treat with notoriously poor clinical outcomes and low survival rates