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Down syndrome and Alzheimers disease: common molecular traits beyond the amyloid precursor protein

2014 Nov 19;19(11):19066-77

A second model additionally included use of lipid-lowering agents, use of ACE inhibitors or angiotensin receptor blockers, use of any anti-hypertensive medication and use of insulin or oral hypoglycaemic agents (yes/no) (model 2)

GSH Nebraska: general info + transporters Comprehensive reviews The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?2017 Tissue distribution and concentration 2-5 mM according to the tissue (5 mM = 1,5366 mg/ml) half-life GSH half life It ranges from 3/5 hours to 30/50 hours If we assume 40kg tissues with an average 2.5 mM GSH (ca 750 mg/l) it means 30 g GSH in the whole body with an half-life of 48hours its life is around 10 days

ROS can damage myelin and oligodendrocytes, the cells responsible for myelin production, leading to demyelination