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Third, given their reliance on lipid metabolism, B1 and MZB cells are extremely susceptible to lipid peroxidation and subsequent ferroptosis secondary to ROS accumulation 142

After completion of biosynthesis, secondary metabolites like GSLs and flavonoids, which are present at high concentrations in the cell, need to be imported into the vacuole ( Figure 2 , the identity is unknown), stored there or further metabolized and/or transported ( Figure 3 , transporters 16 and 17)

[DOI] [PubMed] [Google Scholar] 250.Levine B, Kroemer G

The solution was diluted two-fold with ion-exchange water

Higher-concentration compounded preparations require a prescriber and informed consent