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It was also found that segmentation increased monocyte adhesion and the expression of adhesion molecules in TNF--treated HUVECs at the center but not at the edge of the well [224]

Hunt A, Harrington D, Robinson S
Khrle J, Frdrich C (2022) Deiodinases control local cellular and systemic thyroid hormone availability
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If no irritation occurs after another two weeks, you might consider moving to a 2-3% product
