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Gut microbial alterations in arginine metabolism determine bone mechanical adaptation

For instance, 4-hydroxyl 2, 3-nenonal (HNE) is a marker of unsaturated lipid oxidation, which it has many cellular toxic effects such as irreversible formation of protein adduct and inhibition of GPx activity, and thus contributes in elevated levels of H 2 O 2 [7]

871 Oxidative stress is characterized by MDA and 4-HNE, and their roles in cartilage degeneration and subchondral bone remodeling during OA development have received extensive attention

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