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Propionic acidemia is often diagnosed in the neonatal period, with characteristic patterns for organic acids and acylglycine in urine

Here, phenobarbital (PHB), which belongs to the barbiturate class of drugs, was selected as the typical representative of neurotoxins (Rubio et al., 2022), since PHB was not only abused but also often deliberately overdose for suicide or other purposes (resulting in acute and chronic intoxication) (Yanai et al., 1985

Gemss Asadi et al