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J.LeskelaS.JaraC.GreenH.Avall-LundqvistE.WheelerH

Studies in human epithelial cell lines, fibroblasts, and primary human monocyte-derived macrophages identified that NRF2 activation was directly inhibitory of STING and its downstream pathway, a finding that was reversed with NRF2 inhibition [38]
Antiinflammatory effects arise through inhibition of NFB and MAPK signaling, reducing levels of COX2, IL6, and TNF in the tumor microenvironment

Okuda, Y., Okuda, M
Cisplatin mediates cytotoxicity primarily by binding to DNA and forming intra- and inter-strand crosslinks, resulting in DNA adducts between guanine and adenine bases 84