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The endogenous endocannabinoid system (ECS) is represented by a molecular signaling network consisting of endocannabinoids, specific G-protein-coupled receptors (GPCRs), cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), and specific enzymes responsible for the synthesis, transport, and degradation of endocannabinoids [59]

*Correspondence: Joaquin J

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10.1161/ATVBAHA.111.242594 54

Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer