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Neurotoxicity is apparently dose-dependent (frequent for 250350 mg/m 2 , almost certain if dosage exceeds 500600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]

Pfefferkorn CM, Jiang Z, Lee JC (2012) Biophysics of -synuclein membrane interactions

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Microb Cell Fact 22 , 67 (2023)
They become hyper-reactive, firing off inflammatory chemicals in response to minor triggers like foods, temperature changes, or stress
