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Indigenous medicinal plants like Ashwagandha (withaferin A) trigger apoptosis and radiosensitization in aggressive breast cancer cells (261, 262), while curcumin from turmeric inhibits NF-B signaling pathways and increases the effectiveness of chemotherapy (263)

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Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)

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