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Additionally, trials of oligonucleotide therapeutics and some small-molecule NNMT inhibitors in vitro and in preclinical animal models have validated NNMT as a promising therapeutic target to prevent or treat obesity and related T2D, but currently, clinical trials have not yet been reported

What they do not have is a body of controlled evidence showing that injecting them causes clinically significant weight loss independent of diet, exercise, and the rest of a supervised program

Molecular Metabolism 45:101165

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