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6E, F) and significantly reduced the positive expression of -H2AX and 8-OHDG (Fig

The biosynthesis of autophagosomes involves the appearance of a phagophore in the cytoplasm, which then expands, sequestering cytosomal components, before eventually sealing to form a spherical double-membraned vesicle called the autophagosome The newly-formed autophagosome then translocates to and fuses with the lysosome to form an autolysosome

USA 101 , 1107611081 (2004)

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561 These findings highlight potential therapeutic targets for liver repair and regeneration