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It is increasingly recognized in both cardiovascular and neurodegenerative disorders, where KHcy of proteins such as synuclein and DJ1 drives aggregation and toxicity[17, 18, 56]
In an experimental study carried out by Chen Y et al., 2018, it was determined that, in Sprague Dawley rats fed a High fat diet (HFD) during 12 weeks, the authors demonstrated that APS1 significantly reduced body weight and also reduced the accumulation of hepatic lipids regulating the expression of SIRT-1/PGC-1/SREBP-1, as well as the increase in hepatic antioxidant activity on modulating the expression of activity of NRF-2 and HO-1 [51]
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doi: 10.1016/j.cyto.2013.03.011 61 BunpoPDudleyACundiffJKCavenerDRWekRCAnthonyTG
