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Ultimately, hypometabolism in multiple brain regions occurs as the disease progresses

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Mainly the NCOA4-, NADPH oxidase 4 (NOX4)-, activating transcription factor 3 (ATF3)-and p53-mediated mechanisms are crucial in modulating iron metabolism, lipid peroxidation and antioxidant defenses, thereby affecting the vulnerability to ferroptosis under physiological and pathological conditions (Fig