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Description

Carbamidomethyl (C), Oxidation (M), Deamidated (NQ) and Glutathione (SG) as variable modifications

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Among FDA-approved ADCs, commonly utilized payloads include: derivative of auristatin (MMAE), derivatives of maytansinoid (DM1 and DM4), derivatives of camptothecin (SN-38 and DXd) and DNA alkylators (calicheamicin and PBD) [221, 222]