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Functions of melanin in the body Melanin performs several important functions: Photoprotection - filters sunlight before it can damage skin cells Antioxidant action - neutralizes free radicals formed under UV radiation influence Thermoregulation - dark skin better absorbs and dissipates heat DNA protection - prevents mutations in skin cells What determines melanin levels Genetic factors The genetically determined level of pigmentation is called constitutive pigmentation

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In the tumor microenvironment (TME), conditions such as hypoxia, glucose deprivation, and lactic acid accumulation alter the energy demands of tumor cells, driving metabolic reprogramming in lipid uptake, synthesis, and oxidation

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