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Despite the omission of the term integrative, Wieland et al.s study is a valuable starting point for the development of the present studys operational definition, as they detailed how they constructed their definition, such as considering the historical context of a therapy, whether it is a standard treatment within the dominant medical system, whether it is a standard treatment for a given condition, and the setting in which the therapy is provided [27]

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Finally, we aimed to determine whether the three site-specific histone acetylation marks are found at DSBs