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GPX converts peroxides and hydroxyl radicals to non-toxic forms by oxidizing GSH to glutathione disulfide, which is then reduced to GSH by glutathione reductase ( The antioxidant response is modulated mainly by the Nrf2/Keap1 system (Figure 2)

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10.1038/s41586-019-1678-1 79 ZhangY.ZhaiZ.DuanJ.WangX.ZhongJ.WuL.et al (2022)