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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Cebrian J., Messeguer A., Facino R., Garcia Anton J

The 1950s brought further progress in developing peptide therapy

Laboratory studies have demonstrated: Increased collagen synthesis Upregulation of COL1A1 and COL3A1 gene expression in fibroblast cultures Enhanced glycosaminoglycan production Increased decorin and versican expression MMP modulation Balanced regulation of matrix metalloproteinase activity Reduced matrix degradation Decreased expression of matrix-degrading enzymes Antioxidant Signaling GHK-Cu exhibits antioxidant properties through multiple mechanisms: Gene Expression Modulation Microarray studies have shown that GHK-Cu influences the expression of hundreds of genes

Belimumab (Benlysta) Belimumab (brand name Benlysta) is the first biologic agent (approved in March 2011) specifically for the treatment of lupus

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