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In the context of obesity, the aberrant expansion of white adipose tissue (WAT) is accompanied by extensive macrophage infiltration and activation, which drives chronic inflammation and fibrotic progression

174 In contrast, negative regulators of the NLRP3 inflammasome, such as the E3 ligase A20/TNF--induced protein 3 and TGF--activated kinase 1 (TAK1), prevent its excessive activation and suppress inflammation

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10.1016/j.drudis.2012.05.003 [DOI] [PubMed] [Google Scholar] 37.P

They may be used in combination with insulin therapy to reduce insulin doses and aid in weight management
