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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

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PMID: 27 GovernaVde OliveiraKGBng-RudenstamAOfferSCerezo-MagaaMLiJet al

Although female dogs are typically suspected to have a twofold increased risk of certain autoimmune diseases (including IMHA), a 2016 report from University of California-Davis showed that compared to intact dogs, neutered dogs had an increased risk for autoimmune diseases, and that female dogs had an increased risk compared to males, but not for IMHA.25 Historical findings of IMHA are highly variable

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