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Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia

deficiencies of vitamin B12, folate or niacin, and infective causes including cryptococcal meningitis, HIV, Lyme disease, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, syphilis and Whipple's disease

There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant

It helps balance NO levels to protect the endothelial lining of blood vessels, ensuring they remain flexible and resilient rather than inflamed