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Horton et al

Nevertheless, these studies clearly show benefits of parasitic infections on disease progression (58, 117) and support the hypothesis that parasitic infections are in part responsible for the lower incidence of MS in endemic areas (117)

Oncology 67 , 9397 (2004)

Townsend D and Tew K: Cancer drugs, genetic variation, and the glutathione-S-transferase gene family.Am J Pharmacogenomics 2003

In more detail, on elevated hypoxia conditions, the high level of HIF-1 increases ACE1 and downregulates ACE2 receptors, also because of the impairment of ACE2 due to SARS-CoV-2 infection, developing the complications of disease (Li et al., 2020b