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Both in vitro and in vivo studies demonstrated that the TMSNs-loaded gel exhibited significantly higher retention of tacrolimus (ex vivo rat skin) and led to a significant reduction in ear thickness and improved histology in the mice (in vivo) [131]

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The restrictions have, in effect, relegated the substances to a grey market, fed by suppliers overseas raising new safety concerns as users inject themselves with unvetted substances

Obrosova, 2009)

Chronic wound infections, catheter-associated urinary tract infections, ear infections, and lung infections in cystic fibrosis patients are all biofilm-driven