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DAB (3,3-Diaminobenzidine) and fluorescence staining were performed manually

[8] It transports pyruvate, a key gluconeogenic substrate, to the liver for glucose synthesis

Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues

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