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Recombinant Human TNF alpha (HZ-1014) inhibits growth of L-929 cells in a dose-dependent manner (blue curve)

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Besides surgical debulking, therapies used for GBM management (radiation, chemotherapy, and steroids) enhance microenvironment acidification and, although often providing a time-limited disease control, will thus favor tumor recurrence and complications

Various studies have been performed recently too, such as this one by the US National Library of Medicine, but there is no conclusive evidence of it working for skin lightening yet