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GLP-1-induced nausea results from delayed gastric emptying and direct receptor activation in the brainstems area postrema not oxidative stress

mGlu 2/3 activation also reduces amphetamine-induced DA release in the rat dorsal striatum (Pehrson and Moghaddam, 2010) and cocaine-induced DA release in the caudate nucleus of squirrel monkeys (Bauzo et al., 2009)

However, standard clinical practice in peptide therapy uses milligram-range dosing (12 mg) to achieve meaningful systemic concentrations

doi:10.1523/jneurosci.0195-11.2011 13

Reichert CO, de Freitas FA, Sampaio-Silva J, Rokita-Rosa L, Barros P et al (2020) Ferroptosis mechanisms involved in neurodegenerative diseases
