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The complexity of thiol redox regulation necessitates advanced redox proteomics to map tissue- and site-specific SSG modifications, given their low abundance and instability (99)

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The members of SULT1A family were found in liver, brain, breast, intestine, jejunum, lung, adrenal gland, endometrium, placenta, kidney and in blood platelets

Industrial & Engineering Chemistry Research., 59 (19), 91169126

However, two arguments support a different GSH binding mode in MGST1: 1) in electron crystallography maps of MPGES1 the horseshoe shape of GSH could be observed at a similar resolution 26 , and 2) MGST1 has the unique ability to use N-acetyl-L-cysteine as substrate supporting a different GSH site (discussed further below)