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In a proof-of-concept clinical trial, supplementation of NAC in chronic schizophrenia patients ( N = 140) led to improvements of negative symptoms 17 , auditory mismatch negativity 18 , and local neural synchronization in electroencephalography (EEG) 19 as well as decreased side effects of antipsychotics 17

The adjustments are as follows: (1) For simplicity, we treat cytosolic serine and glycine as constant

Importantly, the sustained cellular stress and inflammatory status found in the COVID-19 patients post-recovery was not associated with initial disease severity, since this inflammatory profile was observed regardless of patient classification at the acute phase of the disease as inpatients (closed symbols) or outpatients (open symbols) ( Figure 7 and Supplementary Figure 6 )