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Chinese Medical Journal 2026 , 139 (2) , 182-199

Guha, M

The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues

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Initial cyber-chatter suggested that people who lose weight with GLP-1 receptor agonists also lose more fat-free mass (FFM) or lean body mass (LBM) than is desirable (though many might say that any loss of LBM or FFM is undesirable), and more than might be expected for similar weight loss achieved through caloric restriction