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Dopamine cannot cross BBB on its own

ROS Generation and Signaling The major known forms of ROS include superoxide anion radical (O 2 ), hydrogen peroxide (H 2 O 2 ) and/or hydroxyl radical (OH)
They may yield scrambled disulfides without subsequent isomerization steps

Steatohepatitis: a tale of two hits

ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain