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Halsted, J
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In all the analyses, we kept the number of entrapment proteins similar to that of the organism specific proteins, and consequently there were 6173 (human) + 6622 (entrapment) proteins and 207,061 (human) + 155,776 (entrapment) peptides in HeLaProt, 10,639 (human) + 10,649 (entrapment) proteins and 358,849 (human) + 270,503 (entrapment) peptides in PanProt, and 20,163 (human) + 19,226 (entrapment) proteins and 585,934 (human) + 455,253 (entrapment) peptides in HumanProt (see Methods and Supplementary Table 2 for details)

Cuprizone is a copper chelator and considering that dysregulation of copper homeostasis in humans can lead to neurodegenerative diseases such as Menkes disease [86, 87], Wilsons diseases [88] and is thought to contribute to Alzheimers disease and Parkinsons disease [88, 89], better understanding potential mechanisms underlying demyelination mediated by copper chelation is necessary to better understand cuprizone toxicity
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