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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

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10.3389/fvets.2020.00591 [DOI] [PMC free article] [PubMed] [Google Scholar] 152.Nemati Z, Ahmadian H, Besharati M, Lesson S, Alirezalu K, Dominguez R, et al

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