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It phosphorylates upstream stimulatory factor 1 (USF1) and then upregulate fatty acid synthase (FASN), which promotes de novo lipogenesis (DNL) in liver and aggravates hepatic fat deposition

Jan 21, 2026 At the molecular level, IGF-1 LR3 represents one of the most significant modifications ever made to a growth factor

Zhenzhong Liu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Insulin sensitivity and glucose handling

This study demonstrates a therapeutic effect of glutathione by oral administration in patients with NAFLD