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A study conducted in Nigeria revealed that approximately 216.8 million people reside in rural areas with limited access to healthcare facilities, including specialized care for chronic illnesses [55]

Administration of meldonium at a dose of 300 mg/kg bw/day for four weeks before inducing sepsis in animals showed an increased activity of tissue copper-zinc SOD, manganese SOD, catalase (CAT), and glutathione peroxidase (GSH-Px) and reduced levels of lipid peroxidation, TNF, phospho-nuclear factor kappa B p65 form (p-NF-B p65), and the Bax/Bcl-2 apoptotic marker ratio, suggesting the anti-inflammatory and anti-apoptotic effects of meldonium [31,32]

The CCK-8 results showed that cell viability decreased in a concentration- and time-dependent manner following emodin treatment at both 24 and 48 h, compared with the control group ( Figure 1A ), suggesting that emodin may inhibit the proliferation of HCCLM3 cells

doi: 10.1073/pnas.91.8.2890