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The albumin quotient (Q alb ), a key marker of BBB permeability, has been found to be elevated in several studies involving individuals with preclinical AD, mild cognitive impairment (MCI), and established AD itself (Halliday et al

Mahmoodi M, et al

Bartzokis, G., Lu, P

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More importantly, this reaction occurs spontaneously in the inner mitochondrial membrane (complexes I to V) via electron transport chain reactions, where free electrons react with oxygen molecules