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(2018) demonstrated a gut-brain signaling axis in a mouse model of NEC in which activation of intestinal TLR-4 signaling led to release of high-mobility group box 1 (HMGB1) protein in the intestine, which in turn, promoted activation of TLR-4 on brain microglial cells resulting in accumulation of reactive oxygen species, loss of oligodendrocyte premature cells, dysmyelination, and cognitive impairment

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But its benefits extend far beyond cellular health

doi: 10.2174/1871529x10909040293

"GLP-1 medications are truly a breakthrough in weight management, but they can also create significant nutrient gaps in things like vitamin B12, vitamin D, iron and calcium," says Matthew Taylor, Sr