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Gradual deterioration of renal function leads to ESRD in the 4th to 5th decade, which is the primary cause of death in patients with untreated Fabry disease 9,10

Citrulline source also appears influential: pure L-citrulline supplements typically provided higher daily doses (610 g) and showed more consistent vascular benefits, whereas watermelon products delivered lower citrulline equivalents (1.52.3 g/day) and yielded mixed results, possibly due to additional bioactive compounds (e.g., lycopene, vitamin C) exerting independent effects

Loffredo FS, Pancoast JR, Cai L, Vannelli T, Dong JZ, Lee RT, et al

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