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System Xc is an antiporter composed of SLC7A11 and SLC3A2, which mediates the cellular uptake of extracellular cystine for GSH synthesis ( 3 Ferroptosis in PCOS 3.1 Core pathophysiological features of PCOS and ferroptosis Ovulatory dysfunction in PCOS often leads to oligomenorrhea or amenorrhea, which reduces iron loss through menstruation

As a static interactome, it lacks dynamic simulations or wet-lab validation, an aspect that is currently being explored for future work

To modulate the immune response, several strategies are suggested such as adjusting the size and sequence chemistry of the mRNA and nucleotides, modifying the charge of the LNP by changing the lipid composition and chemistry, addition of adjuvants in case of vaccines, or exploring different routes of administration

doi: 10.1016/S0015-0282(01)03229-0 [DOI] [PubMed] [Google Scholar] 83