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Indeed, we found that addition of CoA reduced the inhibition of PDHC by SNO-CoA (20 M) in a dose-dependent manner, with 0.5 and 4 mM CoA preventing ~50% and ~75% of the activity loss, respectively (Fig

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Effector T cells play an important function in the immune response to cancer

Our proposed model suggests that the specificity to act as deSUMOylase might preferentially be determined by the specificity in targeting SUMO1 or SUMO2/3 in the S1 site

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