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Another study revealed that pravastatin, an inhibitor of cholesterol biosynthesis, induced Mdm2 Ser166 phosphorylation, which increased Mdm2 ubiquitin ligase activity, attenuated p53 degradation and inhibited the DDR in hepatocytes 118

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doi: 10.1016/j.foodchem.2012.04.136 134

But in dermatology, some research remains limited