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(2021) 320:C37591

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Initially, introduced in the 1920s [10], MetS is characterized as a collection of related cardiometabolic risk factors, including hyperglycemia [11], central obesity, hyperinsulinemia and insulin resistance [12], hypertension, elevated triglycerides, low high-density lipoprotein cholesterol (HDL-C), and high total cholesterol levels

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DNA oxidation has been thought to be associated with cancer initiation